Alex C. Spyropoulos, MD received his medical degree from the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, PA. He completed his internship and residency in internal medicine at the University of New Mexico Health Sciences Center in Albuquerque, NM. He is board certified in Internal Medicine.
Dr. Spyropoulos was Founder and former Medical Director of the Clinical Thrombosis Center in Albuquerque, New Mexico. He is a Professor of Medicine at the Zucker School of Medicine at Hofstra/Northwell and System Director of Anticoagulation and Clinical Thrombosis Services for the multi hospital Northwell Health System in NY. He is also a Professor of the Institute for Health Systems Science as part of the Feinstein Institutes for Medical Research. He is co-chair of the Council on Leadership of Thrombosis at Northwell Health System. He is a Fellow of the American College of Physicians, American College of Chest Physicians, International Academy of Clinical and Applied Thrombosis/Haemostasis, and the Royal College of Physicians, Canada.
Dr. Spyropoulos has helped to develop protocols using low molecular weight heparin in outpatient-based treatment of venous thromboembolic disease, patient self-testing of warfarin, perioperative “bridging” for patients on chronic anticoagulation, medical inpatient and extended thromboprophylaxis, the use of anticoagulants for heparin-induced thrombocytopenia, clinical use of the direct oral anticoagulants, including their use in special patient populations and periprocedural situations, and finally in COVID-19 coagulopathy. Dr. Spyropoulos has lectured extensively both nationally and internationally on these issues.
He has been involved as Principal Investigator, Scientific Committee member, Steering and Executive Committee member, or member of Data Safety Monitoring Board in multiple international, multicenter randomized trials in thrombosis and anticoagulant therapy, including the National Institute of Health BRIDGE trial, the Kids DOTT trial, the Canadian Institute for Healthcare Research PAUSE trial, the COVAC-TP trial, the PREVENT-HD trial, and the MICHELLE trial. He was the Chair or co-Chair of the Executive Committee for the global MARINER and national HEP-COVID and IMPROVE-DD trials of medical and COVID-19 inpatients, as well as Principal Investigator of the CORE-19 registry of post-discharge outcomes in hospitalized COVID-19 patients, respectively He is a founding member of ATLAS, a US-based ARO-CRO in thrombosis-related research.
He was a Steering Committee member for World Thrombosis Day as part of the International Society of Thrombosis and Haemostasis (ISTH), a Steering Committee member of the North American Thrombosis Forum, was Chair of the 2020 Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis, lead for the same group’s 2022 Antithrombotic Guidelines in non-critically ill hospitalized COVID-19 patients and Chair of the same 2022 ISTH Antithrombotic Guidance Statements in COVID-19 inpatients, a member of the World Health Organization’s Global COVID-19 Anticoagulation Collaborative Group, a member of the Anticoagulation Forum and the Thrombosis/Haemostasis Society of North America, co-author of the 8th, 9th and co-Chair of the 10th 2022 American College of Chest Physicians Perioperative Guidelines on Antithrombotic Therapy, and co-author and senior author of the 2008, 2013, and 2023 International Consensus Statement Guidelines in Venous Thromboembolism. He is a panel member of the 2020-2021 National Heart, Lung, and Blood Institute’s Workshop on State of the Science Manifestations of Pulmonary Embolism.
He is on the editorial staff for Hospital Medicine. He is a reviewer for many journals.
Dr. Spyropoulos’ research studies, articles, letters, and editorials have been published in nearly 300 peer-reviewed journals including The New England Journal of Medicine, Blood, Blood Advances, Circulation, Lancet Hematology, Lancet, Annals of Internal Medicine, American Journal of Hematology, JAMA Internal Medicine, American Journal of Medicine, Journal of the American Heart Association, Chest, Thrombosis Haemostasis, American Journal of Cardiology, Journal of Thrombosis and Haemostasis , Journal of the American College of Cardiology, Clinical Applied Thrombosis and Haemostasis, and Thrombosis Research. He also has edited multiple book chapters on the topic of antithrombotic therapy.