Peripheral artery disease (PAD) is the buildup of atherosclerotic plaque in the peripheral arteries and is often combined with the same disease in the coronary arteries. If left untreated PAD can lead to impairment in walking and eventually wounds and gangrene in toes. In addition it can lead to myocardial infarction, stroke, amputation, and death. To provide the best care to your patients, start by knowing the PAD Basics.